The anime is structured into two distinct halves. The first half takes place almost entirely within the Shounan Special Reform School. This section functions as a survival thriller. The boys are subjected to inhumane cruelty at the hands of their captors, specifically the sadistic guard Ishihara and the perverse doctor Sasaki. The narrative here is claustrophobic, tense, and often difficult to watch due to the graphic depiction of physical and psychological abuse.

If "Nishaburo Roku Bou no Shichinin" specifically refers to a lesser-known or older title, it might require more effort to find through official channels, but sticking to legal platforms ensures you're accessing content safely and ethically.

Unlike many shōnen or seinen titles that centre on a single protagonist, Nisha Rokubō employs an ensemble cast. The seven main characters—Kōji, Katsumi, Tokichi, Shintarō, Ichirō, Toshiro, and Jirō—each bring distinct backgrounds (soldier, orphan, laborer, etc.) and personal traumas. The narrative interweaves their individual backstories with the present hardships of the prison, creating a layered tapestry that highlights both personal and collective suffering.