Ensure you are using a USB 2.0 port if available; some older Wilcom dongles struggle with USB 3.0/3.1 (blue ports).
Wilcom ES 2006 utilizes a Hardware Key (Dongle)—typically a USB Sentinel SuperPro or HASP key—to validate the software license. The error occurs because the Windows 10 operating system cannot recognize the legacy dongle driver, or the physical dongle is malfunctioning. wilcom 2006 security device not found windows 10 link
The dongle was the size of a pack of gum, branded with the faded logo “Wilcom 2006.” It was the security key for her digitizing software—the ancient, beloved program she used to turn customer’s JPEGs into embroidery files. The program had paid for her house. It had sewn her daughter’s first Halloween costume. And it absolutely, positively refused to run on Windows 10. Ensure you are using a USB 2