The Gain Trials, initiated in 2010, were designed to assess the effectiveness of a combination treatment for preventing pertussis in children. The study involved approximately 30,000 participants, aged 6 months to 6 years, who were randomized to receive either the Tdap vaccine, azithromycin, or a placebo. The primary objective was to evaluate the efficacy of the interventions in preventing pertussis.
If you have played before, version 1.6.1 will feel familiar yet treacherous. Here are the headline changes introduced by Bladerune9 in this patch: The Gain Trials -v1.6.1- By Bladerune9
Previous versions allowed players to hoard defensive items. In v1.6.1, every point of Gain inflicts "Erosion"—a permanent debuff to your maximum health that only resets upon death. This forces players to finish the run quickly rather than stalling to power up. You are now on a literal clock. The Gain Trials, initiated in 2010, were designed