While physical retail copies typically require the disc to be inserted to play due to basic DRM (Digital Rights Management), modern digital versions provide more flexible, "no-CD" experiences. Playing Without a CD: Official Options

If you are looking for "no-CD" or DRM-free versions to avoid using physical discs, official digital stores offer versions that do not require a CD to run:

The series is known for its swashbuckling adventure, witty humor, and clever puzzles. Players take on the role of Guybrush Threepwood as he navigates the high seas, battles infamous pirates, and uncovers hidden treasures.

Monkey Island: Special Edition Collection is a dual-pack containing the remastered versions of The Secret of Monkey Island Monkey Island 2: LeChuck’s Revenge

This collection is a masterclass in how to remaster a beloved classic. It offers: