Ensure your game is actually v1.0.0.1 (Classic) and not the Definitive Edition , as trainers for one will rarely work on the other.
Move the trainer files (often including an .exe and .ini) into the pc folder where the main game executable is located. mafia 2 trainer v1.0.0.1
to increase the game's internal limits, allowing for more complex world interactions [5.1]. Physics Manipulation Ensure your game is actually v1