You might be tempted to walk away, but CoC2 rewards curiosity. Chests protected by these puzzles often contain: Used for enchanting your gear.
Faster method: Check a nearby bookshelf, corpse, or altar. 90% of the time, the solution is written somewhere within the same screen.
Some chests require you to observe a flash of runes or colors and repeat them back.
So, what was all that brainpower worth?
Are you stuck on a or a particular grid size (like the 4x4 or 5x5) right now?